Human herpesvirus-6 (HHV-6) is a neurotropic virus that has been associated with a wide variety of neurologic disorders, including encephalitis, mesial temporal lobe epilepsy, and multiple sclerosis. [Note: HHV-6 has also long been suspected as playing a role in chronic fatigue syndrome (ME/CFS) in conjunction with Epstein-Barr Virus/mononucleosis, and can persist in the brain tissue after evidence of primary infection has disappeared from the blood, according to the HHV-6 Foundation.]
Currently, the route of HHV-6 entry into the CNS [central nervous system – brain and spinal cord] is unknown.
Using autopsy specimens, we found that the frequency of HHV-6 DNA in the olfactory bulb/tract region was among the highest in the brain regions examined. [Note: the olfactory (odor sensing) system includes receptors in the roof of the nose which connect with the olfactory nerve, which terminates in the olfactory bulb (part of the brain), which in turn connects to parts of the cortex and amygdala.]
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