An Etiological Model for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Kindling might represent a heuristic model [to be tested] for understanding the etiology of Myalgic Encephalomyelitis/chronic fatigue syndrome (ME/CFS).

Kindling occurs when an organism is exposed repeatedly to an initially sub-threshold stimulus re-sulting in hypersensitivity and spontaneous seizure-like activity.

Among patients with ME/CFS:

• Chronically repeated low-intensity stimulation due to an infectious illness might cause kindling of the limbic-hypothalamic-pituitary axis.

• Kindling might also occur by high-intensity stimulation (e.g., brain trauma) of the limbic-hypothalamic-pituitary axis.

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One thought on “An Etiological Model for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

  1. It’s really a nice and helpful piece of information. I’m glad that you shared this helpful info with us. Please keep us informed like this. Thanks for sharing.

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