Clinical trials have shown SAM-e to be comparable to prescription antidepressants for depression and as effective as NSAIDs for osteoarthritis. But, as SAM-e supports the body’s natural mood and inflammation modulating functions, it doesn’t have all the negative side effects associated with those drugs.
SAM-e (S-adenosyl methionine) was first discovered in Italy in 1952 by G.L. Cantoni. An Italian firm developed it as a pharmaceutical in the early 1970s but it wasn’t brought to America until 1999. Although SAME-e has been approved as a drug in at least 14 countries, it is sold as a dietary supplement in the U.S.